Protein markers for the differential diagnosis of vascular dementia and Alzheimer's disease.

International journal of proteomics Pub Date : 2012-01-01 Epub Date: 2012-06-04 DOI:10.1155/2012/824024

A H Simonsen, N-O Hagnelius, G Waldemar, T K Nilsson, J McGuire

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引用次数: 17

Abstract

Alzheimer's disease (AD) is the most common form of dementia found in all human populations worldwide, while vascular dementia (VaD) is the second most common form of dementia. New biomarkers for early and specific diagnosis of AD and VaD are needed to achieve greater insight into changes occurring in the brain and direct therapeutic strategies. The objective of this explorative study was to discover candidate protein biomarkers for the differential diagnosis between VaD and AD. Surface-enhanced laser desorption/ionization (SELDI) TOF-MS was used to differentially profile proteins and peptides in CSF samples from 28 AD patients and 21 patients with VaD. A combination of univariate (Kruskal-Wallis) and multivariate (independent component analysis) statistical approaches produced a list of 27 proteins and peptides that could differentiate between VaD and AD. These markers represent various physiological processes, such as protein degradation (ubiquitin), protease inhibition (cystatin C and alpha-1-antichymoptrypsin), and inflammation (C3a and C4a) that are known to be represented in neurodegenerative diseases.

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血管性痴呆和阿尔茨海默病鉴别诊断的蛋白质标志物

阿尔茨海默病(AD)是全世界所有人群中最常见的痴呆形式，而血管性痴呆(VaD)是第二常见的痴呆形式。需要新的生物标志物用于AD和VaD的早期和特异性诊断，以更深入地了解大脑中发生的变化并指导治疗策略。本探索性研究的目的是发现VaD和AD鉴别诊断的候选蛋白生物标志物。采用表面增强激光解吸/电离(SELDI) TOF-MS对28例AD患者和21例VaD患者脑脊液样品中的蛋白质和肽进行了差异分析。单变量(Kruskal-Wallis)和多变量(独立成分分析)统计方法的结合产生了27种可以区分VaD和AD的蛋白质和肽的列表。这些标记物代表了各种生理过程，如蛋白质降解(泛素)、蛋白酶抑制(胱抑素C和α -1-抗乳胰酶)和炎症(C3a和C4a)，这些已知在神经退行性疾病中具有代表性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International journal of proteomics

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