Association of cerebral microbleeds in acute ischemic stroke with high serum levels of vascular endothelial growth factor.

Archives of neurology Pub Date : 2012-09-01 DOI:10.1001/archneurol.2012.459

Pooja Dassan, Martin M Brown, Simone M Gregoire, Geoffrey Keir, David J Werring

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引用次数: 17

Abstract

Objective: To determine whether vascular endothelial growth factor (VEGF) levels are associated with the presence of cerebral microbleeds (CMBs) in patients after acute ischemic stroke.

Design: A cross-sectional study that used blood samples obtained within 24 hours of symptom onset from patients who experienced acute stroke to measure VEGF levels by enzyme immunoassay. A validated CMB rating scale was used to analyze acutely acquired magnetic resonance images, with the rater blind to clinical details and VEGF levels.

Setting: Accident and Emergency Department at University College Hospital, London, England.

Patients: Twenty patients who experienced acute ischemic stroke.

Main outcome measures: Presence of CMBs and serum level of VEGF.

Results: Five of the 20 patients with acute ischemic stroke (25%) had CMBs. The median VEGF level in the CMB group was significantly higher than that in the group without CMBs (P = .003).

Conclusion: An increase in vascular permeability secondary to a raised VEGF level may have a role in the genesis of CMBs in patients with acute ischemic stroke.

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急性缺血性卒中脑微出血与血清血管内皮生长因子高水平的关系。

目的:探讨急性缺血性脑卒中后血管内皮生长因子(VEGF)水平与脑微出血(CMBs)的关系。设计:一项横断面研究，使用急性中风患者症状发作24小时内的血液样本，通过酶免疫分析法测量VEGF水平。使用经过验证的CMB评分量表分析急性获得的磁共振图像，评分者对临床细节和VEGF水平不知情。地点:英国伦敦大学学院医院急诊科。患者:20例急性缺血性脑卒中患者。主要观察指标:CMBs的存在和血清VEGF水平。结果:20例急性缺血性脑卒中患者中有5例(25%)存在CMBs。CMB组中位VEGF水平显著高于无CMB组(P = 0.003)。结论:血管通透性的增加继发于VEGF水平的升高可能在急性缺血性卒中患者CMBs的发生中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of neurology 医学-临床神经学

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