The role of bacteria in the pathogenesis of ulcerative colitis.

Journal of signal transduction Pub Date : 2012-01-01 Epub Date: 2012-04-24 DOI:10.1155/2012/704953
Maiko Sasaki, Jan-Michael A Klapproth
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引用次数: 78

Abstract

Factors implicated in the pathophysiology of ulcerative colitis (UC) are an abnormal immune response, defect in intestinal epithelial barrier function, and gut microbiota. Currently, it is unclear whether specific bacterial strains are responsible for the induction of intestinal inflammation, but increased bacterial tissue invasion has been described in affected UC patients. Further, a quantitative and qualitative microbial imbalance in UC, defined as dysbiosis, has been characterized by an increase in Rhodococcus spp., Shigella spp., and Escherichia spp., but a decrease in certain Bacteroides spp.. More specifically, Campylobacter spp., Enterobacteriae, and enterohepatic Helicobacter were more prevalent in tissue sample from UC patients subjected to molecular detection methods, but not controls. In addition, serologic testing identified Fusobacterim varium as a potential contributor to the intestinal inflammation in UC. Interestingly, in-situ hybridization studies have shown anti-inflammatory Lactobacillus spp. and Pediococcus spp. were absent in samples from subjects affected by UC. Therefore, dysbiosis is a factor in the pathogenesis of UC.

细菌在溃疡性结肠炎发病机制中的作用。
溃疡性结肠炎(UC)的病理生理因素包括免疫反应异常、肠上皮屏障功能缺陷和肠道微生物群。目前,尚不清楚是否特定的细菌菌株负责诱导肠道炎症,但在受影响的UC患者中已经描述了细菌组织入侵的增加。此外,UC中定量和定性的微生物失衡被定义为生态失调,其特征是红球菌、志贺氏菌和埃希氏菌的增加,但某些拟杆菌的减少。更具体地说,弯曲杆菌、肠杆菌和肠肝幽门螺杆菌在UC患者的组织样本中更普遍,但对照组没有。此外,血清学检测确定了多样梭杆菌作为UC肠道炎症的潜在贡献者。有趣的是,原位杂交研究表明,在UC患者的样本中没有抗炎乳杆菌和Pediococcus。因此,生态失调是UC发病的一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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