A flexible and qualitatively stable model for cell cycle dynamics including DNA damage effects.

Gene regulation and systems biology Pub Date : 2012-01-01 Epub Date: 2012-04-11 DOI:10.4137/GRSB.S8476
Clark D Jeffries, Charles R Johnson, Tong Zhou, Dennis A Simpson, William K Kaufmann
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引用次数: 3

Abstract

This paper includes a conceptual framework for cell cycle modeling into which the experimenter can map observed data and evaluate mechanisms of cell cycle control. The basic model exhibits qualitative stability, meaning that regardless of magnitudes of system parameters its instances are guaranteed to be stable in the sense that all feasible trajectories converge to a certain trajectory. Qualitative stability can also be described by the signs of real parts of eigenvalues of the system matrix. On the biological side, the resulting model can be tuned to approximate experimental data pertaining to human fibroblast cell lines treated with ionizing radiation, with or without disabled DNA damage checkpoints. Together these properties validate a fundamental, first order systems view of cell dynamics. Classification Codes: 15A68.

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一个灵活和定性稳定的细胞周期动力学模型,包括DNA损伤效应。
本文包括一个细胞周期建模的概念框架,实验人员可以在其中绘制观察到的数据并评估细胞周期控制的机制。基本模型表现出定性稳定性,即无论系统参数的大小如何,其实例都保证是稳定的,即所有可行的轨迹都收敛于某一轨迹。定性稳定性也可以用系统矩阵特征值实部的符号来描述。在生物学方面,所得到的模型可以调整到接近电离辐射处理的人类成纤维细胞系的实验数据,有或没有禁用DNA损伤检查点。这些性质共同验证了细胞动力学的基本一阶系统观点。分类代码:15A68。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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