Do environmental toxicants contribute to allergy and asthma?

Alternative Medicine Review Pub Date : 2012-03-01
Walter J Crinnion
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Abstract

The rates of asthma and allergy (Type 1 hypersensitivity disorders) have been increasing worldwide for the last few decades. Various theories have been proposed to account for this alarming trend. One of these is the impact of environmental toxicants. Epidemiological research has correlated exposure to environmental chemicals (such as pesticides, solvents, and air pollutants) with increasing rates of both asthma and allergies. Research has documented chemicals as causal agents capable of producing immune system imbalances characteristic of type 1 hypersensitivity. In vitro studies and in vivo animal models have demonstrated that many of the environmental chemicals and pollutants that have been epidemiologically associated with increased allergic tendency have been shown to enhance Type 2 helper T cell (Th2) dominance, which is consistent with the T-helper cell pattern found in asthma, allergic rhinitis, and other Type 1 hypersensitivity disorders. Depletion of glutathione is one possible mechanism for this T-helper cell imbalance. Preliminary evidence suggests the possibility that repletion of glutathione levels (with oral supplementation of N-acetylcysteine), and enhancement of glutathione transferase function (using sulforaphanes), might be therapeutic options for countering type 1 hypersensitivity disorders caused by environmental chemicals.

环境毒物会导致过敏和哮喘吗?
在过去的几十年里,世界范围内哮喘和过敏(1型超敏性疾病)的发病率一直在上升。人们提出了各种理论来解释这一令人担忧的趋势。其中之一是环境毒物的影响。流行病学研究表明,暴露于环境化学物质(如杀虫剂、溶剂和空气污染物)与哮喘和过敏症发病率的增加有关。研究证明,化学物质是导致免疫系统失衡的原因,具有1型过敏症的特征。体外研究和体内动物模型表明,在流行病学上与过敏倾向增加相关的许多环境化学物质和污染物已被证明可增强2型辅助性T细胞(Th2)优势,这与哮喘、过敏性鼻炎和其他1型超敏性疾病中发现的T辅助细胞模式一致。谷胱甘肽耗竭是辅助性t细胞失衡的一种可能机制。初步证据表明,补充谷胱甘肽水平(口服补充n -乙酰半胱氨酸)和增强谷胱甘肽转移酶功能(使用硫素)可能是对抗由环境化学物质引起的1型超敏性疾病的治疗选择。
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来源期刊
Alternative Medicine Review
Alternative Medicine Review 医学-全科医学与补充医学
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