High-sensitivity C reactive protein: associations with cardiovascular risk factors and tracking in female adolescents and young adults.

ISRN pediatrics Pub Date : 2011-01-01 Epub Date: 2011-01-24 DOI:10.5402/2011/707206

John A Morrison, Charles J Glueck, Stephen R Daniels, Ping Wang, Davis M Stroop, Paul S Horn

{"title":"High-sensitivity C reactive protein: associations with cardiovascular risk factors and tracking in female adolescents and young adults.","authors":"John A Morrison, Charles J Glueck, Stephen R Daniels, Ping Wang, Davis M Stroop, Paul S Horn","doi":"10.5402/2011/707206","DOIUrl":null,"url":null,"abstract":"<p><p>Objective. We assessed adolescent anthropometry, lipids, insulin, glucose, and blood pressures to identify factors associated with high-sensitivity C-reactive protein (hsCRP) and its tracking in young adults. Methods. Ten-year prospective study of 589 schoolgirls, 321 black, 268 white. Results. HsCRP did not differ (P > .08) by race or oral contraceptive use. HsCRP tracked from age 16 to 25 (r = 0.77), 16 to 26 (r = 0.50), 24 to 26 (r = 0.66), and 25 to 26 (r = 0.71), all P ≤ .02. By stepwise regression, at age 16, waist circumference accounted for 44.8% of hsCRP variance; BMI accounted for 33.1%, 34.4%, and 31.1% at ages 24, 25, and 26, P < .0001 for all. Changes in cholesterol and BMI were associated with change in hsCRP from age 24-26 (partial R(2) = 12.3% P < .0001, 6.6% P = .0012). Changes in BMI and triglyceride (partial R(2) = 8.5% P = .0001, 3.3%, P = .0045) were associated with change in hsCRP from age 25 to 26. Conclusions. HsCRP tracks from age 16 to 26, with BMI, waist circumference, and cholesterol as major determinants.</p>","PeriodicalId":73521,"journal":{"name":"ISRN pediatrics","volume":"2011 ","pages":"707206"},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/707206","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ISRN pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5402/2011/707206","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/1/24 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 4

Abstract

Objective. We assessed adolescent anthropometry, lipids, insulin, glucose, and blood pressures to identify factors associated with high-sensitivity C-reactive protein (hsCRP) and its tracking in young adults. Methods. Ten-year prospective study of 589 schoolgirls, 321 black, 268 white. Results. HsCRP did not differ (P > .08) by race or oral contraceptive use. HsCRP tracked from age 16 to 25 (r = 0.77), 16 to 26 (r = 0.50), 24 to 26 (r = 0.66), and 25 to 26 (r = 0.71), all P ≤ .02. By stepwise regression, at age 16, waist circumference accounted for 44.8% of hsCRP variance; BMI accounted for 33.1%, 34.4%, and 31.1% at ages 24, 25, and 26, P < .0001 for all. Changes in cholesterol and BMI were associated with change in hsCRP from age 24-26 (partial R(2) = 12.3% P < .0001, 6.6% P = .0012). Changes in BMI and triglyceride (partial R(2) = 8.5% P = .0001, 3.3%, P = .0045) were associated with change in hsCRP from age 25 to 26. Conclusions. HsCRP tracks from age 16 to 26, with BMI, waist circumference, and cholesterol as major determinants.

查看原文本刊更多论文

高敏感性C反应蛋白:与心血管危险因素的关联及其在女性青少年和年轻人中的追踪

目标。我们评估了青少年的人体测量、血脂、胰岛素、葡萄糖和血压，以确定与高敏c反应蛋白(hsCRP)相关的因素及其在年轻人中的追踪。方法。589名女学生的10年前瞻性研究，321名黑人，268名白人。结果。HsCRP没有因种族或口服避孕药使用而差异(P > .08)。HsCRP随访年龄为16 ~ 25岁(r = 0.77)、16 ~ 26岁(r = 0.50)、24 ~ 26岁(r = 0.66)、25 ~ 26岁(r = 0.71)， P均≤0.02。逐步回归发现，16岁时腰围占hsCRP方差的44.8%;BMI在24岁、25岁和26岁时分别占33.1%、34.4%和31.1%，P均< 0.0001。24-26岁时胆固醇和BMI的变化与hsCRP的变化相关(部分R(2) = 12.3% P < 0.0001, 6.6% P = 0.0012)。BMI和甘油三酯的变化(部分R(2) = 8.5% P = 0.0001, 3.3%， P = 0.0045)与25 - 26岁hsCRP的变化相关。结论。HsCRP从16岁追踪到26岁，BMI、腰围和胆固醇是主要的决定因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ISRN pediatrics

自引率

0.00%

发文量