The influence of dopamine receptor d4 polymorphism on resting EEG in healthy young females.

Q4 Medicine
Open Neuroimaging Journal Pub Date : 2012-01-01 Epub Date: 2012-03-02 DOI:10.2174/1874440001206010019
Tien-Wen Lee, Younger W-Y Yu, Chen-Jee Hong, Shih-Jen Tsai, Hung-Chi Wu, Tai-Jui Chen
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引用次数: 5

Abstract

The polymorphism of variable number of tandem repeat (VNTR) in dopamine receptor D4 (DRD4) gene exon III has been linked to various neuro-psychiatric conditions with disinhibition/impulsivity as one of the core features. This study examined the modulatory effects of long-allele variant of DRD4 VNTR on the regional neural activity as well as inter-regional neural interactions in a young female population. Blood sample and resting state eyes-closed EEG signals were collected in 233 healthy females, stratified into two groups by polymerase chain reaction: long-allele carriers (>4- repeat) and non-carriers (<=4-repeat/<=4-repeat). The values of mean power of 18 electrodes and mutual information of 38 channel pairs across theta, alpha, and beta frequencies were analyzed. Our connectivity analysis was based on information theory, which combined Morlet wavelet transform and mutual information calculation. Between-group differences of regional power and connectivity strength were quantified by independent t-test, while between-group differences in global trends were examined by non-parametric analyses. We noticed that DRD4 VNTR long-allele was associated with decreased global connectivity strength (from non-parametric analysis), especially over bi-frontal, biparietal and right fronto-parietal and right fronto-temporal connections (from independent t-tests). The between-group differences in regional power were not robust. Our findings fit with the networks of response inhibition, providing evidence bridging DRD4 long-allele and disinhibition/impulsivity in neuropsychiatric disorders. We suggest future DRD4 studies of imaging genetics incorporate connectivity analysis to unveil its impact on cerebral network.

Abstract Image

多巴胺受体d4多态性对健康年轻女性静息脑电图的影响。
多巴胺受体D4 (DRD4)基因外显子III的可变数目串联重复序列(VNTR)多态性与多种神经精神疾病有关,而去抑制/冲动是其核心特征之一。本研究研究了DRD4 VNTR长等位基因变异对年轻女性群体区域神经活动和区域间神经相互作用的调节作用。采集健康女性233例血样和静息状态闭眼脑电图信号,采用聚合酶链反应将其分为长等位基因携带者(>4-重复)和非携带者(>4-重复)两组。
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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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