Gait kinematic analysis evaluates hindlimb revascularization.

Proceedings of the Western Pharmacology Society Pub Date : 2011-01-01

Amelia Ríos, Alexandra Delgado, Bruno Escalante, Jesús Santana

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Abstract

Peripheral arterial occlusive disease is described as vascular disorders associated with ischemia and may be the result of an obstructive vascular process or a lost revascularization response. We have shown that gait locomotion analysis by video filming represents an integrative model for the evaluation of mechanisms involved in the process of ischemia-induced revascularization. However, analysis by this method can be subjective and perception errors may be occurring. We present the optimization of a quantifiable, noninvasive, reproducible method that analyzes ankle kinematics in rats using a two-dimensional digital video system. Gait dynamics were filmed in hindlimb ischemic rats with a high speed digital video camera. Images were collected and analyzed at 125 frames per second. An algorithm using interactive data language (IDL) was devised to assess different parameters. In ischemic rats, stride time and knee joint angle remained altered 10 days post-surgery compared with sham animals. Gait kinematics were outlined in a highly reliable way by this computational analysis and corroborated the notion of hindlimb movement recovery associated with the revascularization process.

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步态运动学分析评估后肢血运重建。

外周动脉闭塞性疾病被描述为与缺血相关的血管疾病，可能是血管阻塞过程或丧失血运重建反应的结果。我们已经证明，通过视频拍摄的步态运动分析代表了评估缺血诱导血运重建过程中涉及的机制的综合模型。然而，这种方法的分析可能是主观的，并且可能发生感知错误。我们提出了一种可量化的、无创的、可重复的方法，该方法使用二维数字视频系统分析大鼠的踝关节运动学。采用高速数码摄像机拍摄后肢缺血大鼠的步态动力学。以每秒125帧的速度收集和分析图像。设计了一种基于交互式数据语言(IDL)的算法来评估不同的参数。缺血大鼠与假手术大鼠相比，术后10天步幅时间和膝关节角度仍有改变。通过这种计算分析，以一种高度可靠的方式概述了步态运动学，并证实了与血运重建过程相关的后肢运动恢复的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the Western Pharmacology Society

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