Insulin receptor substrate-1 expression is increased in circulating leukocytes of patients with acute coronary syndrome.

ISRN cardiology Pub Date : 2011-01-01 Epub Date: 2011-06-16 DOI:10.5402/2011/740585
Manuel F Jiménez-Navarro, Héctor Bueno, Luis Alvarez-Sala, Noela Rodríguez-Losada, Vicente Andrés, Herminia González-Navarro
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引用次数: 5

Abstract

The mechanisms underlying the increased risk of cardiovascular disease associated with diabetes mellitus (DM) are not fully defined. Insulin resistance in human metabolic syndrome patients is associated with decreased expression of the insulin receptor substrate-2- (Irs2-) AKT2 axis in mononuclear leukocytes (MLs). Moreover, acute coronary syndrome (ACS) has been linked through genome-wide association studies to the 2q36-q37.3 locus, which contains the Irs1 gene. Here, we investigated the expression of insulin-signaling pathway genes in MLs from patients with DM, ACS, and ACS plus DM. Quantitative real-time PCR expression studies showed no differences in the mRNA levels of Irs2, Akt2, and Akt1 among all patients. However, Irs1 mRNA expression was significantly increased in patients with ACS-diabetics and nondiabetics-compared with diabetic patients without ACS (P < .02 and P < .005, resp.). The present study reveals for the first time an association between increased Irs1 mRNA levels in MLs of patients with ACS which is not related to DM.

Abstract Image

急性冠脉综合征患者循环白细胞中胰岛素受体底物-1表达升高。
与糖尿病(DM)相关的心血管疾病风险增加的机制尚未完全确定。人代谢综合征患者的胰岛素抵抗与单核白细胞(MLs)中胰岛素受体底物-2- (Irs2-) AKT2轴的表达降低有关。此外,通过全基因组关联研究发现,急性冠脉综合征(ACS)与2q36-q37.3位点有关,该位点含有Irs1基因。在这里,我们研究了糖尿病、ACS和ACS合并DM患者的MLs中胰岛素信号通路基因的表达。实时荧光定量PCR表达研究显示,所有患者的Irs2、Akt2和Akt1的mRNA水平没有差异。然而,与没有ACS的糖尿病患者相比,ACS患者(糖尿病患者和非糖尿病患者)Irs1 mRNA的表达显著升高(P < 0.02和P < 0.005)。本研究首次揭示了ACS患者MLs中Irs1 mRNA水平升高与糖尿病无关的相关性。
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