The role of persistent organic pollutants in the worldwide epidemic of type 2 diabetes mellitus and the possible connection to Farmed Atlantic Salmon (Salmo salar).

Alternative Medicine Review Pub Date : 2011-12-01
Walter J Crinnion
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Abstract

Rates of type 2 diabetes mellitus (T2DM), both in the United States and worldwide, have been rising at an alarming rate over the last two decades. Because this disease is viewed as primarily being attributable to unhealthy lifestyle habits, a great deal of emphasis has been placed on encouraging increased exercise, better dietary habits, and weight loss. Recent studies reveal that the presence of several persistent organic pollutants (POPs) can confer greater risk for developing the disease than some of the established lifestyle risk factors. In fact, evidence suggests the hypothesis that obesity might only be a significant risk factor when adipose tissue contains high amounts of POPs. Chlorinated pesticides and polychlorinated biphenyls, in particular, have been strongly linked to the development of metabolic syndrome, insulin resistance, and T2DM. In addition to reviewing the evidence associating POPs to these conditions, this article explores the possible contribution of farmed Atlantic salmon - a significant and common dietary source of POPs - with blood sugar dysregulation conditions.

持久性有机污染物在全球2型糖尿病流行中的作用及其与养殖大西洋鲑鱼(Salmo salar)的可能联系。
2型糖尿病(T2DM)的发病率,无论是在美国还是在世界范围内,在过去的二十年里都以惊人的速度上升。由于这种疾病被认为主要是由不健康的生活习惯引起的,因此人们非常重视鼓励增加锻炼、改善饮食习惯和减肥。最近的研究表明,几种持久性有机污染物(POPs)的存在比某些既定的生活方式风险因素更容易引发该病。事实上,有证据表明,只有当脂肪组织含有大量持久性有机污染物时,肥胖才可能是一个重要的风险因素。特别是氯化农药和多氯联苯与代谢综合征、胰岛素抵抗和2型糖尿病的发生密切相关。除了回顾将持久性有机污染物与这些疾病联系起来的证据外,本文还探讨了养殖大西洋鲑鱼(一种重要且常见的持久性有机污染物膳食来源)可能对血糖失调状况的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Alternative Medicine Review
Alternative Medicine Review 医学-全科医学与补充医学
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