Comparison of CD63 Upregulation Induced by NSAIDs on Basophils and Monocytes in Patients with NSAID Hypersensitivity.

Journal of allergy Pub Date : 2012-01-01 Epub Date: 2011-12-01 DOI:10.1155/2012/580873

N Abuaf, H Rostane, J Barbara, C Toly-Ndour, H Gaouar, P Mathelier-Fusade, F Leynadier, C Francès, R Girot

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引用次数: 33

Abstract

Background. An in vitro basophil activation test, based on the detection of CD63 upregulation induced by NSAIDs, has been described. Its clinical significance remains controversial. Objectives. In patients with a history of nonallergic NSAID hypersensitivity, stratified according to the severity of the symptoms, to assess with NSAIDs the predictive value of basophil (BAT) and monocyte (MAT) activation tests. Patients/Methods. Sixty patients who had NSAIDs-induced or exacerbated urticaria/angiooedema and 20 controls was included. After incubation with NSAIDs or acetaminophen, leukocytes were analysed for CD63 upregulation. Results. With aspirin, the sensitivity (37%) and specificity (90%) of BAT agree with already published results. In contrast, when patients had had cutaneous and visceral reactions, the frequency of positive BAT 14/22 (64%, P < 0.001) or MAT 10/22 (46%, P < 0.01) were increased. Conclusions. Positive tests were more frequent among patients having a severe hypersensitivity contrasting with the other patients who had results similar to controls.

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非甾体抗炎药对非甾体抗炎药过敏患者嗜碱性粒细胞和单核细胞CD63表达上调的比较

背景。体外嗜碱性粒细胞激活试验，基于检测CD63上调诱导的非甾体抗炎药，已经描述。其临床意义仍有争议。目标。在有非过敏性非甾体抗炎药超敏反应史的患者中，根据症状的严重程度分层，用非甾体抗炎药评估嗜碱性粒细胞(BAT)和单核细胞(MAT)激活试验的预测价值。病人/方法。60例非甾体抗炎药引起或加重的荨麻疹/血管水肿患者和20例对照组纳入研究。用非甾体抗炎药或对乙酰氨基酚孵育后，分析白细胞CD63的上调。结果。对于阿司匹林，BAT的敏感性(37%)和特异性(90%)与已发表的结果一致。相比之下，当患者有皮肤和内脏反应时，BAT 14/22阳性(64%，P < 0.001)或MAT 10/22阳性(46%，P < 0.01)的频率增加。结论。与其他结果与对照组相似的患者相比，严重超敏反应患者的阳性检测更为频繁。

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Journal of allergy

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