Association of six-minute walk distance (6MWD) with resting pulmonary function in patients with chronic obstructive pulmonary disease (COPD).

Osaka city medical journal Pub Date : 2011-06-01

Hiroki Fujimoto, Kazuhisa Asai, Tetsuya Watanabe, Hiroshi Kanazawa, Kazuto Hirata

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Abstract

Background: The six-minute walk test (6MWT) is widely used for integrated assessment of patients with chronic obstructive pulmonary disease (COPD). However, little is known concerning which resting pulmonary function test measurements relate to six-minute walk distance (6MWD).

Methods: We retrospectively analyzed consecutive data of spirometry, lung volume analysis, and measurements of diffusing capacity of the lung for carbon monoxide (DLCO) and 6MWT from total of one-hundred and thirty patients with COPD. Univariate and multivariate analyses were performed to examine the relationships between 6MWD and variables.

Results: By linear regression analysis, 6MWD was significantly associated with age, weight, BMI, FEV1.0, FEV1.0 (% predicted), IC, TLC, IC/TLC, FEF25-75, DLCO (% predicted), and DLCO/VA. Stepwise multiple regression analysis revealed that age (r2 = 0.173; p < 0.0001), IC (r2 = 0.18; p < 0.0001), and DLCONA (r2 = 0.238; p < 0.0001) significantly accounted for 6MWD.

Conclusions: The present results suggest that age, IC, and DLCONA were significantly associated with 6MWD in patients with COPD.

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慢性阻塞性肺疾病(COPD)患者6分钟步行距离(6MWD)与静息肺功能的关系

背景:6分钟步行试验(6MWT)被广泛用于慢性阻塞性肺疾病(COPD)患者的综合评估。然而，关于静息肺功能测试测量与6分钟步行距离(6MWD)的关系知之甚少。方法:我们回顾性分析了130例COPD患者的连续肺活量测定、肺容量分析以及肺一氧化碳弥散量(DLCO)和6MWT的测量数据。进行单因素和多因素分析，以检验6MWD与变量之间的关系。结果:通过线性回归分析，6MWD与年龄、体重、BMI、FEV1.0、FEV1.0(预测%)、IC、TLC、IC/TLC、FEF25-75、DLCO(预测%)、DLCO/VA显著相关。逐步多元回归分析显示，年龄(r2 = 0.173;p < 0.0001)， IC (r2 = 0.18;p < 0.0001)， DLCONA (r2 = 0.238;p < 0.0001)显著占6MWD。结论:目前的研究结果表明，年龄、IC和DLCONA与COPD患者的6MWD显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Osaka city medical journal

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