Oxaliplatin-induced Pulmonary Fibrosis: Two Case Reports.

Chun-Geun Ryu, Eun-Joo Jung, Gangmi Kim, Su Ran Kim, Dae-Yong Hwang
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引用次数: 10

Abstract

Oxaliplatin with infusional 5-fluorouracil plus leucovorin (FOLFOX regimen) is the one of the standard chemotherapy regimens for treating a colorectal carcinoma. The most common side effects include neutropenia, diarrhea, vomiting and peripheral neuropathy, and these are moderate and manageable. However, pulmonary toxicity is rarely reported to be associated with the FOLFOX regimen. Moreover, there is no established guideline for the management of this side effect. Here, along with a literature review, we report two cases of rapidly developing pulmonary fibrosis related to the use of the FOLFOX regimen in patients with colorectal carcinomas.

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奥沙利铂所致肺纤维化2例报告
奥沙利铂输注5-氟尿嘧啶加亚叶酸钙(FOLFOX方案)是治疗结直肠癌的标准化疗方案之一。最常见的副作用包括中性粒细胞减少、腹泻、呕吐和周围神经病变,这些都是中度和可控的。然而,很少报道与FOLFOX方案相关的肺毒性。此外,对于这种副作用的管理尚无既定的指导方针。在此,我们报告了两例与FOLFOX方案在结直肠癌患者中的应用相关的快速发展的肺纤维化。
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