A ribozyme transcribed by a ribozyme.

Thomas Bentin
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引用次数: 1

Abstract

Prominent current ideas on how life emerged on Earth include an RNA world hypothesis in which RNA performed informational as well as catalytic functions in the absence of both DNA and protein. Demonstration of a self-replicative system based on ribonucleic acid polymers as both information carriers and catalysts would lend support to such a scenario. A pivotal component of this system would be an RNA dependent RNA polymerase ribozyme capable of replicating its own RNA gene. Recent work from the Holliger group at the Laboratory for Molecular Biology in Cambridge has provided synthetic ribozymes1 that just might foreshadow the future engineering of such self-replicative systems.

核酶由核酶转录的核酶
目前关于生命如何在地球上出现的主要观点包括RNA世界假说,其中RNA在缺乏DNA和蛋白质的情况下发挥信息和催化作用。基于核糖核酸聚合物作为信息载体和催化剂的自我复制系统的演示将为这种情况提供支持。该系统的关键组成部分将是RNA依赖的RNA聚合酶核酶能够复制自己的RNA基因。剑桥分子生物学实验室的霍利格小组最近的工作提供了合成核糖酶,这可能预示着这种自我复制系统的未来工程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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