Micro soft tissues visualization based on x-ray phase-contrast imaging.

The open medical informatics journal Pub Date : 2011-01-01 Epub Date: 2011-07-27 DOI:10.2174/1874431101105010019
Lu Zhang, Shuqian Luo
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引用次数: 13

Abstract

The current imaging methods have a limited ability to visualize microstructures of biological soft tissues. Small lesions cannot be detected at the early stage of the disease. Phase contrast imaging (PCI) is a novel non-invasive imaging technique that can provide high contrast images of soft tissues by the use of X-ray phase shift. It is a new choice in terms of non-invasively revealing soft tissue details. In this study, the lung and hepatic fibrosis models of mice and rats were used to investigate the ability of PCI in microstructures observation of soft tissues. Our results demonstrated that different liver fibrosis stages could be distinguished non-invasively by PCI. The three-dimensional morphology of a segment of blood vessel was constructed. Noteworthy, the blood clot inside the vessel was visualized in three dimensions which provided a precise description of vessel stenosis. Furthermore, the whole lung airways including the alveoli were obtained. We had specifically highlighted its use in the visualization and assessment of the alveoli. To our knowledge, this was the first time for non-invasive alveoli imaging using PCI. This finding may offer a new perspective on the diagnosis of respiratory disease. All the results confirmed that PCI will be a valuable tool in biological soft tissues imaging.

Abstract Image

Abstract Image

Abstract Image

基于x射线相衬成像的显微软组织可视化。
目前的成像方法对生物软组织微结构的可视化能力有限。在疾病的早期不能发现小的病变。相衬成像(PCI)是一种新型的无创成像技术,它可以利用x射线相移提供软组织的高对比度图像。它是一种新的选择,在非侵入性显示软组织的细节。本研究采用小鼠和大鼠肺和肝纤维化模型,探讨PCI对软组织微结构观察的能力。我们的结果表明,不同的肝纤维化分期可以通过PCI无创区分。构建了一段血管的三维形态。值得注意的是,血管内的血凝块在三维上可视化,提供了血管狭窄的精确描述。此外,还获得了包括肺泡在内的整个肺气道。我们特别强调了它在肺泡的可视化和评估中的应用。据我们所知,这是首次使用PCI进行无创肺泡成像。这一发现可能为呼吸道疾病的诊断提供新的视角。这些结果证实了PCI将是一种有价值的生物软组织成像工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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