Zhenyu Wang, Jonathan S Dordick, Robert J Linhardt
{"title":"Escherichia coli K5 heparosan fermentation and improvement by genetic engineering.","authors":"Zhenyu Wang, Jonathan S Dordick, Robert J Linhardt","doi":"10.4161/bbug.2.1.14201","DOIUrl":null,"url":null,"abstract":"<p><p>N-acetyl heparosan is the precursor for the biosynthesis of the important anticoagulant drug heparin. The E. coli K5 capsular heparosan polysaccharide provides a promising precursor for in vitro chemoenzymatic production of bioengineered heparin. This article explores the improvements of heparosan production for bioengineered heparin by fermentation process engineering and genetic engineering.</p>","PeriodicalId":89091,"journal":{"name":"Bioengineered bugs","volume":"2 1","pages":"63-7"},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/bbug.2.1.14201","citationCount":"50","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioengineered bugs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4161/bbug.2.1.14201","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 50
Abstract
N-acetyl heparosan is the precursor for the biosynthesis of the important anticoagulant drug heparin. The E. coli K5 capsular heparosan polysaccharide provides a promising precursor for in vitro chemoenzymatic production of bioengineered heparin. This article explores the improvements of heparosan production for bioengineered heparin by fermentation process engineering and genetic engineering.
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