Comorbidity of bipolar disorder with substance abuse: selection of prioritized genes for translational research.

Summit on translational bioinformatics Pub Date : 2009-03-01

Raphael D Isokpehi, Sharon A Lewis, Tolulola O Oyeleye, Wellington K Ayensu, Tonya M Gerald

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Abstract

Bipolar disorder is a highly heritable mental illness. The global burden of bipolar disorder is complicated by its comorbidity with substance abuse. Several genome-wide linkage/association studies on bipolar disorder as well as substance abuse have focused on the identification and/or prioritization of candidate disease genes. A useful step for translational research of these identified/prioritized genes is to identify sets of genes that have particular kinds of publicly available data. Therefore, we have leveraged the availability of links to related resources in the Entrez Gene database to develop a web-based resource for selecting genes based on presence or absence in particular biological data resources. The utility of our approach is demonstrated using a set of 3,399 genes from multiple eukaryotes that have been studied in the context of bipolar disorder and/or substance abuse. A web resource to automate the selection of genes that contain certain database links is available at http://compbio.jsums.edu/bpd.

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双相情感障碍与药物滥用的共病:转化研究优先基因的选择。

躁郁症是一种高度遗传性的精神疾病。双相情感障碍的全球负担因其与药物滥用的合并症而复杂化。一些关于双相情感障碍和药物滥用的全基因组联系/关联研究集中在候选疾病基因的识别和/或优先排序上。对这些已识别/优先排序的基因进行转化研究的一个有用步骤是识别具有特定类型公开可用数据的基因集。因此，我们利用了Entrez基因数据库中相关资源链接的可用性，开发了一个基于网络的资源，用于根据特定生物数据资源中的存在或不存在来选择基因。我们的方法的实用性是通过在双相情感障碍和/或药物滥用的背景下研究的来自多种真核生物的一组3399个基因来证明的。一个自动选择包含某些数据库链接的基因的网络资源可在http://compbio.jsums.edu/bpd上获得。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Summit on translational bioinformatics

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