Constipation and diarrhoea - common adverse drug reactions? A cross sectional study in the general population.

Gunvor S Fosnes, Stian Lydersen, Per G Farup
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引用次数: 55

Abstract

Background: Constipation and diarrhoea are common complaints and often reported as adverse drug reactions. This study aimed at finding associations between drugs and constipation and diarrhoea in a general population.

Methods: A selection of inhabitants in Oppland County, Norway participated in a cross-sectional survey. Information about demographics, diseases including gastrointestinal complaints classified according to the Rome II criteria and use of drugs were collected on questionnaires. Constipation was defined as functional constipation and constipation predominant Irritable Bowel Syndrome (IBS), and diarrhoea as functional diarrhoea and diarrhoea predominant IBS. Associations between drugs and constipation and diarrhoea were examined with multivariable logistic regression models. Based on the multivariable model, the changes in prevalence (risk difference) of the abdominal complaints for non-users and users of drugs were calculated.

Results: In total 11078 subjects were invited, 4622 completed the questionnaires, 640 (13.8%) had constipation and 407 (8.8%) had diarrhoea. To start using drugs increased the prevalence of constipation and diarrhoea with 2.5% and 2.3% respectively. Polypharmacy was an additional risk factor for diarrhoea. Use of furosemide, levothyroxine sodium and ibuprofen was associated with constipation, and lithium and carbamazepine with diarrhoea. The excess drug related prevalence varied from 5.3% for the association between ibuprofen and constipation to 27.5% for the association between lithium and diarrhoea.

Conclusions: Use of drugs was associated with constipation and diarrhoea in the general population. The associations are most likely adverse drug reactions and show that drug-induced symptoms need to be considered in subjects with these complaints.

Abstract Image

便秘和腹泻-常见的药物不良反应?在普通人群中进行的横断面研究。
背景:便秘和腹泻是常见的主诉,常被报道为药物不良反应。本研究旨在发现药物与一般人群便秘和腹泻之间的关系。方法:选取挪威奥普兰县的居民进行横断面调查。通过问卷收集了人口统计资料、根据罗马II标准分类的疾病(包括胃肠道疾病)和药物使用情况。便秘定义为功能性便秘和以便秘为主的肠易激综合征(IBS),腹泻定义为功能性腹泻和以腹泻为主的肠易激综合征。用多变量logistic回归模型检验了药物与便秘和腹泻之间的关系。基于多变量模型,计算非吸毒者和吸毒者腹部主诉患病率(风险差异)的变化。结果:共邀请11078名受试者,4622人完成问卷调查,其中便秘640人(13.8%),腹泻407人(8.8%)。开始使用药物后,便秘和腹泻的患病率分别增加了2.5%和2.3%。多种用药是腹泻的另一个危险因素。使用速尿、左旋甲状腺素钠和布洛芬与便秘有关,使用锂和卡马西平与腹泻有关。过量药物相关的患病率从布洛芬和便秘相关的5.3%到锂和腹泻相关的27.5%不等。结论:在一般人群中,药物的使用与便秘和腹泻有关。这些关联很可能是药物不良反应,表明在有这些抱怨的受试者中需要考虑药物引起的症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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