METABOLIC FUNCTIONS OF MYOSTATIN AND GDF11.

Alexandra C McPherron
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Abstract

Myostatin is a member of the transforming growth factor β superfamily of secreted growth factors that negatively regulates skeletal muscle size. Mice null for the myostatin gene have a dramatically increased mass of individual muscles, reduced adiposity, increased insulin sensitivity, and resistance to obesity. Myostatin inhibition in adult mice also increases muscle mass which raises the possibility that anti-myostatin therapy could be a useful approach for treating diseases such as obesity or diabetes in addition to muscle wasting diseases. In this review I will describe the present state of our understanding of the role of myostatin and the closely related growth factor growth/differentiation factor 11 on metabolism.

肌肉生长抑制素和gdf11的代谢功能。
肌生长抑制素是转化生长因子β超家族的一员,可负性调节骨骼肌大小。没有肌肉生长抑制素基因的小鼠个体肌肉质量显著增加,脂肪减少,胰岛素敏感性增加,对肥胖的抵抗力增强。成年小鼠的肌肉生长抑制素抑制也会增加肌肉质量,这增加了抗肌肉生长抑制素治疗可能是治疗肥胖或糖尿病等疾病的有效方法,除了肌肉萎缩疾病之外。在这篇综述中,我将描述我们对肌生长抑制素和密切相关的生长因子/分化因子11在代谢中的作用的理解现状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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