Epidemiological and Clinical Features of Hepatitis B Virus Genotypes among Immigrants in Southern Italy.

Hepatitis research and treatment Pub Date : 2010-01-01 Epub Date: 2010-04-22 DOI:10.1155/2010/878356
Gaetano Scotto, Domenico Martinelli, Rocco Di Tullio, Vincenzina Fazio
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Abstract

Background/aims. This study aims to determine the distribution and clinical features of HBV-genotypes in a population of immigrants affected by HBV-infection. Methods. Between 01/2003 and 03/2009, 1623 immigrants were tested for HBV-infection. Biochemical and virological activities were determined in HBsAg-positive patients; HBV-genotypes were determined, by the INNO-LiPA HBV Genotyping, in the subjects with HBV DNA detectable. In every patient we evaluated the stage and classified the infection as inactive carrier, mild or moderate/severe chronic hepatitis, cirrhosis, and/or HCC. Results. Among the tested subjects, 191 (11.7%) resulted HBsAg-positive, and in 144/191 (75.4%) serum HBV-DNA was detectable. The genotype distribution was as follows: 45,13% genotype E, 18,1% genotype D, 15,3% genotype B, 13,2% genotype C, 4,9% genotype A, 3,5% mixed genotypes (A-D). The evaluation of liver disease degree showed that 24.6% patients were inactive carriers of HBV infection, 19.4% presented a immunotolerance phase, 34.5% had mild chronic hepatitis, 13.6% had a moderate/severe chronic hepatitis, 6.3% had cirrhosis, and 1.6% presented HCC. Conclusions. Our study evidences a high prevalence of HBV-infection in immigrants, and the potentiality of migratory flow in the introduction of genotype non-D hepatitis B virus. The Hepatitis B virus genotypes presented significant differences in epidemiological and clinical characteristics.

意大利南部移民中乙型肝炎病毒基因型的流行病学和临床特征。
背景/目的。本研究旨在确定受 HBV 感染的移民人群中 HBV 基因型的分布和临床特征。研究方法。2003 年 1 月至 2009 年 3 月,1623 名移民接受了 HBV 感染检测。对 HBsAg 阳性患者的生化和病毒学活动进行了测定;通过 INNO-LiPA HBV 基因分型,对检测到 HBV DNA 的受试者的 HBV 基因型进行了测定。我们对每位患者的感染阶段进行了评估,并将其分为非活动性带原者、轻度或中度/重度慢性肝炎、肝硬化和/或 HCC。结果在检测对象中,191 人(11.7%)HBsAg 阳性,144/191 人(75.4%)检测到血清 HBV-DNA。基因型分布如下45.13%为基因 E 型,18.1%为基因 D 型,15.3%为基因 B 型,13.2%为基因 C 型,4.9%为基因 A 型,3.5%为混合基因型(A-D)。肝病程度评估显示,24.6% 的患者为非活动性 HBV 感染携带者,19.4% 的患者处于免疫耐受期,34.5% 的患者患有轻度慢性肝炎,13.6% 的患者患有中度/重度慢性肝炎,6.3% 的患者患有肝硬化,1.6% 的患者患有 HCC。结论我们的研究证明了移民中 HBV 感染的高流行率,以及移民潮引入非 D 基因型乙型肝炎病毒的可能性。乙肝病毒基因型在流行病学和临床特征方面存在显著差异。
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