Gene transcriptional networks integrate microenvironmental signals in human breast cancer.

IF 1.4
Ren Xu, Jian-Hua Mao
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Abstract

A significant amount of evidence shows that microenvironmental signals generated from extracellular matrix (ECM) molecules, soluble factors, and cell-cell adhesion complexes cooperate at the extra- and intracellular level. This synergetic action of microenvironmental cues is crucial for normal mammary gland development and breast malignancy. To explore how the microenvironmental genes coordinate in human breast cancer at the genome level, we have performed gene co-expression network analysis in three independent microarray datasets and identified two microenvironment networks in human breast cancer tissues. Network I represents crosstalk and cooperation of ECM microenvironment and soluble factors during breast malignancy. The correlated expression of cytokines, chemokines, and cell adhesion proteins in Network II implicates the coordinated action of these molecules in modulating the immune response in breast cancer tissues. These results suggest that microenvironmental cues are integrated with gene transcriptional networks to promote breast cancer development.

人类乳腺癌的基因转录网络整合微环境信号。
大量证据表明,由细胞外基质(ECM)分子、可溶性因子和细胞-细胞粘附复合物产生的微环境信号在细胞外和细胞内水平协同作用。这种微环境信号的协同作用对正常乳腺发育和乳腺恶性肿瘤至关重要。为了探索微环境基因在人类乳腺癌中如何在基因组水平上协调,我们在三个独立的微阵列数据集中进行了基因共表达网络分析,并确定了人类乳腺癌组织中的两个微环境网络。网络I代表乳腺恶性肿瘤过程中ECM微环境与可溶性因子的串扰与合作。细胞因子、趋化因子和细胞粘附蛋白在网络II中的相关表达暗示了这些分子在调节乳腺癌组织免疫反应中的协调作用。这些结果表明,微环境信号与基因转录网络相结合,促进了乳腺癌的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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