Microsurgically induced pure arterial aneurysm model in rats.

Central European Neurosurgery Pub Date : 2011-02-01 Epub Date: 2010-12-13 DOI:10.1055/s-0030-1249699

T Mücke, F Hölzle, K-D Wolff, A Harders, M Scholz

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引用次数: 14

Abstract

Introduction: The aim of the study was to develop a reliable and reproducible arterial aneurysm model for microsurgical training and further research with dimensions comparable to those encountered in aneurysms in humans.

Methods: The arterial aneurysm models were created microsurgically at the bifurcation of the abdominal aorta using a graft of the carotid artery in 20 Wistar rats.

Results: The aneurysms were created successfully and no complications occurred. The average volume of this arterial aneurysm model was 35.19±5.64 mm (3). The time required to create this kind of aneurysm was 192±14.4 min. The central zone of blood inflow into the aneurysm was not affected by any thrombus formation.

Conclusion: The presented model at the aortic bifurcation in the rat is reliable and immediately available for microsurgical and technical training as well as for scientific studies on aneurysms. Since this kind of model also reproduces arterial aneurysms, basic techniques such as suturing and microtechniques needed for the dissection and repair of vessels can be taught during its creation.

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显微手术诱导的大鼠纯动脉动脉瘤模型。

前言:本研究的目的是建立一个可靠的、可重复的动脉动脉瘤模型，用于显微外科训练和进一步的研究，其尺寸可与人类动脉瘤相媲美。方法:采用颈动脉移植术在20只Wistar大鼠腹主动脉分叉处建立显微外科动脉瘤模型。结果:动脉瘤形成成功，无并发症发生。该动脉瘤模型的平均体积为35.19±5.64 mm(3)，制造该类动脉瘤所需时间为192±14.4 min。进入动脉瘤中心区的血液未受血栓形成的影响。结论:所建立的大鼠主动脉分叉模型是可靠的，可用于显微手术和技术训练以及动脉瘤的科学研究。由于这种模型也可以复制动脉瘤，因此在创建过程中可以教授血管解剖和修复所需的缝合和显微技术等基本技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central European Neurosurgery CLINICAL NEUROLOGY-NEUROSCIENCES

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>12 weeks