Cycloaddition chemistry of allenamides.

Abstract

Allenamides are electron-deficient equivalents of allenamines, which can participate in a range of cycloaddition reactions giving rise to novel heterocycles and diverse molecular architectures similar to those contained in natural products. This review summarizes some of the research conducted in this field, with particular reference to predicting the stereochemical outcomes of such transformations. The applications of allenamides in cycloaddition transformations are highlighted, providing insight into the potential utility of this under-used synthon.