Stephen B. Shears, Nikhil A. Gokhale, Huanchen Wang, Angelika Zaremba
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在认为18岁即为成年的国家,2011年可能是二磷酸肌醇多磷酸盐正式被描述为“成年”的时间点,因为这些分子在1993年首次被完全定义(Menniti等人,1993;Stephens et al., 1993b)。但从生物学的角度来看,这些多磷酸盐不能完全被认为已经成熟到独立作用于细胞内信号的地位。本综述讨论了几种已发表的关于二磷酸肌醇多磷酸可能起作用的机制的建议。我们认为,所有这些假设都需要进一步发展。我们还不知道一种单一的分子机制,通过这种机制可以控制特定二磷酸肌醇多磷酸水平的变化。然而,尽管我们的理解存在这些差距,但人们一直期待这些分子在信号传导领域具有巨大的潜力。这反映了我们对所有青少年的期望,我们应该真诚地希望在不久的将来,二磷酸肌醇多磷酸终于长大了。