Distribution of bone marrow-derived cells in the vestibular end organs and the endolymphatic sac.

Takayuki Okano, Takayuki Nakagawa, Juichi Ito
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引用次数: 11

Abstract

Conclusion: Bone marrow-derived cells (BMDCs) are constitutively present in the vestibular end organs and in the endolymphatic sac, and may play a role in the maintenance of inner ear homeostasis.

Objectives: The aim was to examine the distribution and characteristics of BMDCs in the vestibular end organs and in the endolymphatic sac.

Methods: Bone marrow-chimeric mice were generated by bone marrow transplantation from mice genetically labeled with enhanced green fluorescent protein to C57 Bl/6 mice to visualize BMDCs. Three months after bone marrow transplantation, inner ear specimens were processed for histochemical analyses.

Results: BMDCs were widely distributed in the vestibular end organs and the endolymphatic sac, whereas there were differences in the phenotype and the distribution between the vestibular end organs and the endolymphatic sac. A subpopulation of BMDCs in the vestibular end organs expressed antigen-presenting protein MHC class II. Moreover, the density of BMDCs in the vestibular end organs increased in response to local mechanical stress.

骨髓源性细胞在前庭终末器官和内淋巴囊中的分布。
结论:骨髓源性细胞(bmdc)组成性地存在于前庭终末器官和内淋巴囊中,并可能在维持内耳稳态中发挥作用。目的:探讨BMDCs在前庭终末器官和内淋巴囊内的分布和特征。方法:将基因标记为增强绿色荧光蛋白的小鼠骨髓移植到C57 Bl/6小鼠中,形成骨髓嵌合小鼠,以观察BMDCs。骨髓移植3个月后,对内耳标本进行组织化学分析。结果:BMDCs广泛分布于前庭终末器官和内淋巴囊,但前庭终末器官和内淋巴囊在表型和分布上存在差异。前庭终末器官的BMDCs亚群表达抗原呈递蛋白MHC II类。前庭末端器官BMDCs的密度随局部机械应力的增加而增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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