{"title":"S-Nitrosothiol biology and therapeutic potential in metabolic disease.","authors":"Christopher G Kevil, Rakesh P Patel","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>S-Nitrosothiols (RSNOs) have been used widely as experimental nitric oxide (NO) donors, but the clinical use of these agents remains limited. Recent data support a role for endogenous RSNOs as mediators of NO signaling via the post-translational modification of proteins. This review discusses the increased understanding of the role of RSNOs in NO signaling, as well as emerging insights into NO donor-dependent and -independent mechanisms of action of RSNOs, in the context of emerging and potential therapeutics that target endogenous RSNOs or use synthetic RSNOs to stimulate NO signaling. The focus of this review is the treatment of diabetes and metabolic disease, pathologies in which dysfunction in NO signaling is clearly implicated.</p>","PeriodicalId":10978,"journal":{"name":"Current opinion in investigational drugs","volume":"11 10","pages":"1127-34"},"PeriodicalIF":0.0000,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677214/pdf/nihms474369.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in investigational drugs","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
S-Nitrosothiols (RSNOs) have been used widely as experimental nitric oxide (NO) donors, but the clinical use of these agents remains limited. Recent data support a role for endogenous RSNOs as mediators of NO signaling via the post-translational modification of proteins. This review discusses the increased understanding of the role of RSNOs in NO signaling, as well as emerging insights into NO donor-dependent and -independent mechanisms of action of RSNOs, in the context of emerging and potential therapeutics that target endogenous RSNOs or use synthetic RSNOs to stimulate NO signaling. The focus of this review is the treatment of diabetes and metabolic disease, pathologies in which dysfunction in NO signaling is clearly implicated.
s -亚硝基硫醇(RSNOs)已被广泛用作实验性一氧化氮(NO)供体，但这些药物的临床应用仍然有限。最近的数据支持内源性RSNOs通过蛋白质的翻译后修饰作为NO信号传导介质的作用。这篇综述讨论了在新兴和潜在的治疗方法中，针对内源性RSNOs或使用合成RSNOs刺激NO信号传导的背景下，对RSNOs在NO信号传导中的作用的日益了解，以及对NO供体依赖和独立的RSNOs作用机制的新见解。本综述的重点是糖尿病和代谢性疾病的治疗，其中NO信号功能障碍明显涉及的病理。
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
