Inhibitory effect of aqueous and ethanolic garlic (Allium sativum L., Lilliaceae) extracts on the rat atria.

Clinical and Experimental Hypertension (New York, N.y. : 1993) Pub Date : 2010-01-01 DOI:10.3109/10641960903265238

Mirjana Radenkovic, Suzana Brankovic, Dusanka Kitic, Slavimir Veljkovic, Vesna Ivetic, Milkica Nesić, Bojana Miladinovic

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引用次数: 2

Abstract

The acute negative inotropic and chronotrophic effects of aqueous and alcoholic garlic extracts (Allium sativum L.) on spontaneous and adrenalin-stimulated contractions of the Wistar rat atria were investigated. The addition of garlic extracts to isolated rat atria evoked negative inotropic and chronotropic effects. Ethanolic garlic extract exerts much stronger negative inotropic (58.33 +/- 14.76%) effects than aqueous extract (43.66 +/- 16.32%). The difference in frequency reduction is especially conspicuous. Aqueous garlic extract very slightly affects the frequency, while ethanolic extract reduces it by more than 40%. In addition to these effects, the positive inotropism and chronotropism induced by the addition of noradrenaline, were much more antagonized by ethanolic garlic extract than by aqueous extract. Moreover, ethanolic garlic extract establishes sinus rhythm in the atria with extrasystoles induced by noradrenaline.

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大蒜(Allium sativum L.， Lilliaceae)提取物对大鼠心房的抑制作用。

研究了大蒜水提物和酒精提物对Wistar大鼠心房自发收缩和肾上腺素刺激收缩的急性负性肌力和慢性衰老作用。大蒜提取物对离体大鼠心房有负性肌力和变时作用。大蒜醇提物的负性肌力效应(58.33 +/- 14.76%)明显强于水提物(43.66 +/- 16.32%)。频率降低的差异尤其明显。大蒜水提取物对频率的影响很小，而乙醇提取物能降低40%以上。此外，大蒜醇提物对去甲肾上腺素诱导的正性肌力和慢性肌力的拮抗作用比水提物强得多。此外，乙醇大蒜提取物在去甲肾上腺素诱导的心房早搏中建立窦性心律。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical and Experimental Hypertension (New York, N.y. : 1993)

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