{"title":"Discussion on \"A Hybrid Selection and Testing Procedure with Curtailment for Comparative Clinical Trials\" by Elena M. Buzaianu and Pinyuen Chen.","authors":"Peter F Thall","doi":"10.1080/07474940802619170","DOIUrl":null,"url":null,"abstract":"<p><p>Buzaianu and Chen apply strong curtailment to modify the two-stage select-and-test clinical trial design proposed by Thall et al. (1988). The modification reduces the expected sample size while maintaining overall power but requires continuous monitoring in stage 1. I will review the history of this type of design and discuss practical issues related to the use of strong curtailment that arise in trial conduct.</p>","PeriodicalId":516303,"journal":{"name":"Sequential Analysis","volume":"28 1","pages":"41-43"},"PeriodicalIF":0.0000,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900801/pdf/nihms183727.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sequential Analysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/07474940802619170","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Buzaianu and Chen apply strong curtailment to modify the two-stage select-and-test clinical trial design proposed by Thall et al. (1988). The modification reduces the expected sample size while maintaining overall power but requires continuous monitoring in stage 1. I will review the history of this type of design and discuss practical issues related to the use of strong curtailment that arise in trial conduct.
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