{"title":"Neurovascular photoacoustic tomography.","authors":"Song Hu, Lihong V Wang","doi":"10.3389/fnene.2010.00010","DOIUrl":null,"url":null,"abstract":"<p><p>Neurovascular coupling refers to the relationship between neuronal activities and downstream hemodynamic responses. Photoacoustic tomography (PAT), enabling comprehensive label-free imaging of hemodynamic activities with highly scalable penetration and spatial resolution, has great potential in the study of neurovascular coupling. In this review, we first introduce the technical basis of hemodynamic PAT - including label-free quantification of total hemoglobin concentration, blood oxygenation, and blood flow - as well as its applications in hemodynamic monitoring. Then, we demonstrate the potential application of PAT in neurovascular imaging by highlighting representative studies on cerebral vascular responses to whisker stimulation and Alzheimer's disease. Finally, potential research directions and associated technical challenges are discussed.</p>","PeriodicalId":88242,"journal":{"name":"Frontiers in neuroenergetics","volume":"2 ","pages":"10"},"PeriodicalIF":0.0000,"publicationDate":"2010-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899522/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in neuroenergetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fnene.2010.00010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2010/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Neurovascular coupling refers to the relationship between neuronal activities and downstream hemodynamic responses. Photoacoustic tomography (PAT), enabling comprehensive label-free imaging of hemodynamic activities with highly scalable penetration and spatial resolution, has great potential in the study of neurovascular coupling. In this review, we first introduce the technical basis of hemodynamic PAT - including label-free quantification of total hemoglobin concentration, blood oxygenation, and blood flow - as well as its applications in hemodynamic monitoring. Then, we demonstrate the potential application of PAT in neurovascular imaging by highlighting representative studies on cerebral vascular responses to whisker stimulation and Alzheimer's disease. Finally, potential research directions and associated technical challenges are discussed.
神经血管耦合是指神经元活动与下游血液动力学反应之间的关系。光声断层扫描（PAT）能以高度可扩展的穿透力和空间分辨率对血液动力学活动进行全面的无标记成像，在神经血管耦合研究中具有巨大潜力。在这篇综述中，我们首先介绍了血液动力学 PAT 的技术基础--包括总血红蛋白浓度、血氧饱和度和血流量的无标记量化--及其在血液动力学监测中的应用。然后，我们通过重点介绍有关脑血管对胡须刺激和阿尔茨海默病反应的代表性研究，展示了 PAT 在神经血管成像中的潜在应用。最后，我们讨论了潜在的研究方向和相关的技术挑战。
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