[Analysis on the effects of hepatitis B vaccine to prevent mother-to-children transmission of hepatitis B virus in Shunyi District of Beijing Municipal].

Abstract

Objective: To evaluate the effects of immunization strategy about Hepatitis B vaccine preventing mother-to-children transmission (MTCT)of Hepatitis B virus (HBV) in Shun Yi District of Beijing.

Methods: The supervision data of blood serum of the children born from mothers who HBsAg carrier or HBsAg and HBeAg carrier were collected during the years of 2005-2008. The positive rate of HBsAg, anti-HBs, anti-HBc and the protective rate were analyzed.

Results: 223 children born from mothers of HBsAg and HBeAg carrier or HBsAg carrier were vaccinated according to the Hepatitis B vaccine immunigation strategy of Beijing. The infective rate of HBV was 1.18%, and protective rate of HepB was 98.61%. The infective rate of HBV of the children born from mothers of HBsAg and HBeAg carrier was higher than the rate of the children born from mothers of HBsAg carrier. The positive rate of anti-HBs was 84.71%. There were statistics significance in different years. The GMC of anti-HBs was 139.32 mIU per mL. The anti-HBs GMC of 2007 and 2008 were higher than those of 2005 and 2006. The anti-HBs GMC of the children who HBIG adopted was higher than that of the children who HBIG did not adopted.

Conclusion: The Hepatitis B vaccine immunization strategy of Shun Yi District had good immunological and protective effects to prevent HBV perinatal transmission.