Luc Jasmin, Jean-Philippe Vit, Aditi Bhargava, Peter T Ohara
{"title":"Can satellite glial cells be therapeutic targets for pain control?","authors":"Luc Jasmin, Jean-Philippe Vit, Aditi Bhargava, Peter T Ohara","doi":"10.1017/S1740925X10000098","DOIUrl":null,"url":null,"abstract":"<p><p>Satellite glial cells (SGCs) undergo phenotypic changes and divide the following injury into a peripheral nerve. Nerve injury, also elicits an immune response and several antigen-presenting cells are found in close proximity to SGCs. Silencing SCG-specific molecules involved in intercellular transport (Connexin 43) or glutamate recycling (glutamine synthase) can dramatically alter nociceptive responses of normal and nerve-injured rats. Transducing SGCs with glutamic acid decarboxylase can produce analgesia in models of trigeminal pain. Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain.</p>","PeriodicalId":19153,"journal":{"name":"Neuron glia biology","volume":"6 1","pages":"63-71"},"PeriodicalIF":0.0000,"publicationDate":"2010-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S1740925X10000098","citationCount":"144","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuron glia biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1017/S1740925X10000098","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2010/6/22 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 144
Abstract
Satellite glial cells (SGCs) undergo phenotypic changes and divide the following injury into a peripheral nerve. Nerve injury, also elicits an immune response and several antigen-presenting cells are found in close proximity to SGCs. Silencing SCG-specific molecules involved in intercellular transport (Connexin 43) or glutamate recycling (glutamine synthase) can dramatically alter nociceptive responses of normal and nerve-injured rats. Transducing SGCs with glutamic acid decarboxylase can produce analgesia in models of trigeminal pain. Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain.
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