[Paget disease of the vulva: resolution after local treatment with imiquimod--report of a case and review of the literature].

Gynakologisch-geburtshilfliche Rundschau Pub Date : 2009-01-01 Epub Date: 2010-05-19 DOI:10.1159/000301110
Serena Bertozzi, Ambrogio P Londero, Arrigo Fruscalzo, Diego Marchesoni, R J Lellé
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引用次数: 6

Abstract

Paget disease is a rare disorder of the skin of the vulva, comprising less than 1% of vulvar neoplasms. Surgical excision is considered the standard of care. While the invasive variant of Paget disease is rare, frequent local recurrences from non-invasive disease, which are inoperable, constitute a major clinical problem. In this article we report on a 71-year-old patient with recurrent disease treated successfully with imiquimod cream. Symptoms such as local itching subsided shortly after initiation of treatment. Four weeks later, first signs of resolution could be demonstrated colposcopically. Within 8 weeks, complete clinical remission was achieved. Thus, topical imiquimod is not only effective as treatment of vulvar intraepithelial neoplasia, but may also be used for selected patients with recurrent Paget disease as an alternative to repeat surgical interventions.

[外阴Paget病:局部咪喹莫特治疗后的缓解——1例报告及文献复习]。
佩吉特病是一种罕见的外阴皮肤疾病,占外阴肿瘤的不到1%。手术切除被认为是标准的治疗方法。虽然Paget病的侵袭性变异是罕见的,但非侵袭性疾病的频繁局部复发,无法手术治疗,是一个主要的临床问题。在这篇文章中,我们报告了一位71岁的复发性疾病患者使用咪喹莫特乳膏治疗成功。开始治疗后不久,局部瘙痒等症状消退。四周后,阴道镜检查可以看到缓解的第一个迹象。在8周内,达到完全的临床缓解。因此,外用咪喹莫特不仅可有效治疗外阴上皮内瘤变,也可用于复发性Paget病的特定患者,作为重复手术干预的替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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