[Molecular chaperones].

Bioorganicheskaia khimiia Pub Date : 2010-01-01
E E Mel'nikov, T V Rotanova
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Abstract

Chaperones are unique remodeling proteins that participate in a great number of intracellular processes and are involved in the correction of protein structure, the prevention of the aggregation of misfolded proteins, the destruction of protein aggregates, and also the unfolding of native protein targets for their translocation across a membrane. In addition to this, Chaperones assist in the dismantling of active oligomers into inactive unfolded monomers for their subsequent photolytic degradation and the assembly of folded subunits into protein assemblies and specific complexes. Data on the structure and functioning of molecular chaperones from five basic families are summarized in the review.

(分子伴侣’)。
伴侣蛋白是一种独特的重塑蛋白,参与大量的细胞内过程,参与蛋白质结构的纠正,防止错误折叠蛋白质的聚集,破坏蛋白质聚集体,以及展开天然蛋白质靶标以实现其跨膜易位。除此之外,伴侣蛋白还有助于将活性低聚物分解成无活性的未折叠单体,以供其随后的光解降解,并将折叠的亚基组装成蛋白质组件和特定复合物。综述了5个基本科分子伴侣蛋白的结构和功能方面的研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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