A rice variety (HYJA-Ri4) enhances arterial thrombus formation in an animal model of thrombosis.

Pathophysiology of Haemostasis and Thrombosis Pub Date : 2008-01-01 Epub Date: 2009-12-09 DOI:10.1159/000252819

Aki Naemura, Yoshinobu Ijiri, Mitsuhiro Kodama, Yoshinori Honda, Junichiro Yamamoto

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引用次数: 5

Abstract

Epidemiological evidence exists for a causative role of inappropriate diets in the development and clinical outcome of thrombotic diseases. Our previous studies have shown that some fruits and vegetables have antithrombotic activity. As rice is a principal ingredient of everyday food in Japan, the aim of the present study was to determine rice varieties with antithrombotic effect. Western-style high-fat diet containing flour prepared from whole-grain rice of different varieties was fed to atherosclerosis-prone (apolipoprotein E- and low density lipoprotein receptor-deficient) mice for 3 months. A laser-induced carotid-artery thrombosis model was used. None of the five tested rice varieties showed an antithrombotic effect. The effect of HYJA-Ri1, HYJA-Ri2, HYJA-Ri3 and HYJA-Ri5 rice on experimental thrombus formation did not differ significantly from the controls. However, HYJA-Ri4 rice significantly enhanced the thrombotic reaction (p = 0.0078), thus having a prothrombotic effect. Our findings suggest that HYJA-Ri4 rice should not be included in an antithrombotic diet.

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一个水稻品种(HYJA-Ri4)在血栓形成动物模型中促进动脉血栓形成。

流行病学证据表明，不适当的饮食在血栓性疾病的发展和临床结果中的致病作用。我们之前的研究表明，一些水果和蔬菜具有抗血栓活性。由于水稻是日本日常食物的主要成分，本研究的目的是确定具有抗血栓作用的水稻品种。以西式高脂饮食(含不同品种的全米制面粉)喂养动脉粥样硬化易感(载脂蛋白E和低密度脂蛋白受体缺乏)小鼠3个月。采用激光诱导颈动脉血栓形成模型。五种水稻品种均未显示出抗血栓作用。HYJA-Ri1、HYJA-Ri2、HYJA-Ri3和HYJA-Ri5水稻对实验血栓形成的影响与对照组没有显著差异。而HYJA-Ri4水稻显著增强血栓形成反应(p = 0.0078)，具有促血栓形成作用。我们的研究结果表明HYJA-Ri4大米不应该包括在抗血栓饮食中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pathophysiology of Haemostasis and Thrombosis

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