Granulomatous Slack Skin: Assessment of Disease Progression and Treatment Response Using Positron Emission Tomography/Computed Tomography

Youyu Sheng , Lianjun Chen , Zhemin Huang , Zhanglei Mu , Jincheng Kong , Yan Luo , Qinping Yang
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引用次数: 9

Abstract

Granulomatous slack skin (GSS) is an extremely rare subtype of cutaneous T-cell lymphoma. A 14-year-old boy had suffered from progressive infiltrative erythema and plaques that gradually evolved into lax masses and pendulous skin on his axilla, anterior wall of the abdomen, bilateral inguinal region, and thighs. Histopathologic examination of the skin lesion and inguinal lymph node demonstrated granulomatous infiltration with multinucleated giant cells. Positron emission tomography (PET)/computed tomography (CT) scan was performed after acute exacerbation and exhibited slightly high fluorodeoxyglucose (FDG) distribution of skin lesions, without any evidence of abnormality in the metabolism of FDG in lymph nodes or other extralymphatic organs. Concurrent use of corticosteroid and recombinant interferon-α successfully controlled the disease, and posttreatment PET/CT scan confirmed the response to the therapy with decreased levels of FDG uptake. PET/CT is suggested to be helpful in the assessment of disease progression and treatment response in the management of patients with GSS.

肉芽肿松弛皮肤:使用正电子发射断层扫描/计算机断层扫描评估疾病进展和治疗反应
松弛皮肤肉芽肿(GSS)是一种极为罕见的皮肤t细胞淋巴瘤亚型。一个14岁的男孩患有进行性浸润性红斑和斑块,并逐渐发展为腋窝、腹部前壁、双侧腹股沟区和大腿上的松弛肿块和下垂皮肤。皮肤病变及腹股沟淋巴结组织病理检查显示肉芽肿浸润多核巨细胞。急性加重后进行正电子发射断层扫描(PET)/计算机断层扫描(CT)扫描,显示皮肤病变的氟脱氧葡萄糖(FDG)分布稍高,未见淋巴结或其他淋巴外器官FDG代谢异常的证据。同时使用皮质类固醇和重组干扰素-α成功地控制了疾病,治疗后的PET/CT扫描证实了治疗的反应,FDG摄取水平下降。建议PET/CT有助于评估GSS患者的疾病进展和治疗反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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