THE FINE STRUCTURE OF BONE CELLS.

H R Dudley, D Spiro
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引用次数: 265

Abstract

An electron microscopic study of Araldite-embedded, undecalcified human woven and chick lamellar bone is presented. The fine structure of the cells of bone in their normal milieu is described. Active osteoblasts possess abundant granular endoplasmic reticulum, numerous small vesicles, and a few secretion droplets. Their long cytoplasmic processes penetrate the osteoid. The transition of osteoblasts into osteoid osteocytes and then into osteocytes is traced and found to involve a progressive reduction of cytoplasmic organelles. Adjoining the osteocytes and their processes is a layer of amorphous material which is interposed between the cell surfaces and the bone walls of their respective cavities. Osteoclasts contain numerous non-membrane-associated ribosomes, abundant mitochondria, and little granular endoplasmic reticulum, thus differing markedly from other bone cells. The brush border is a complex of cytoplasmic processes adjacent to a resorption zone in bone. No unmineralized collagen is seen at resorption sites and it appears that collagen is removed before or at the time of mineral solution. All bone surfaces are covered by cells, some of which lack distinctive qualities and are designated endosteal lining cells. The structure of osteoid, bone, and early mineralization sites is illustrated and discussed.

骨细胞的精细结构
电子显微镜下的研究,aralte嵌入,未钙化人编织和鸡板层骨。描述了正常环境下骨细胞的精细结构。活跃的成骨细胞具有丰富的颗粒状内质网,大量的小泡和少量的分泌液滴。它们的长细胞质突穿透类骨。从成骨细胞到类骨细胞再到骨细胞的转变被追踪并发现涉及细胞器的逐渐减少。在骨细胞和它们的过程之间是一层无定形的物质,它夹在细胞表面和它们各自腔的骨壁之间。破骨细胞含有大量的非膜相关核糖体,丰富的线粒体和小颗粒内质网,因此与其他骨细胞明显不同。刷状边界是骨吸收带附近的细胞质过程的复合体。在吸收部位未见未矿化的胶原蛋白,似乎胶原蛋白在矿物溶液之前或在矿物溶液时被去除。所有的骨表面都被细胞覆盖,其中一些缺乏独特的品质,被称为内层衬细胞。对类骨、骨和早期矿化部位的结构进行了说明和讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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