Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women.

International urogynecology journal and pelvic floor dysfunction Pub Date : 2009-11-01 Epub Date: 2009-07-04 DOI:10.1007/s00192-009-0948-0

Mary J G Zamboni, Carlos A P Cabral, Francisco J B Sampaio, Luiz E M Cardoso

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引用次数: 1

Abstract

Introduction and hypothesis: Urinary glycosaminoglycans (uGAG) have protective effects against urinary tract disorders. Here we investigated whether oral hormonal contraceptives (OC) affect uGAG excretion.

Methods: Urine specimens were from young women regularly taking: ethinyl estradiol + drospirenone, n = 9; ethinyl estradiol + cyproterone acetate, n = 9; and ethinyl estradiol + gestodene, n = 7. Controls were from ten women not taking OC. Total uGAG was assayed as hexuronic acid/urinary creatinine. Sulfated uGAG species was determined by electrophoresis.

Results: Unlike controls, total uGAG in the two halves of the menstrual cycle was similar in the OC groups. Whole cycle uGAG was higher in the OC groups (p < 0.01), especially for ethinyl estradiol + cyproterone acetate (p < 0.005). The three OC produced decreases of approximately 50% in heparan sulfate (p < 0.02) and dermatan sulfate (p < 0.02), and a approximately 100% increase in chondroitin sulfate (p < 0.004).

Conclusions: uGAG excretion is changed in women taking OC, and this might enhance the protective effects of these molecules against urinary tract disorders.

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口服激素类避孕药影响年轻女性尿糖胺聚糖的浓度和组成。

简介与假设:尿糖胺聚糖(uGAG)对尿路疾病有保护作用。本文研究口服激素避孕药(OC)是否影响ugg排泄。方法:定期服用炔雌醇+屈螺酮的年轻女性尿液标本9例;炔雌醇+醋酸环丙孕酮，n = 9;炔雌醇+孕酮，n = 7。对照组是10名未服用OC的女性。总uGAG以己醛酸/尿肌酐测定。用电泳法测定硫酸uGAG的种类。结果:与对照组不同，OC组月经周期两半的总uGAG相似。OC组全周期ugg显著高于对照组(p < 0.01)，以雌二醇+环丙孕酮组尤显著(p < 0.005)。三种OC产生的硫酸肝素(p < 0.02)和硫酸皮素(p < 0.02)减少约50%，硫酸软骨素增加约100% (p < 0.004)。结论:服用OC的女性uGAG排泄发生改变，这可能增强了这些分子对尿路疾病的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International urogynecology journal and pelvic floor dysfunction

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