Cough and dyspnea during bronchoconstriction: comparison of different stimuli.

Cough (London, England) Pub Date : 2009-06-25 DOI:10.1186/1745-9974-5-6

Thais R Suguikawa, Clecia A Garcia, Edson Z Martinez, Elcio O Vianna

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引用次数: 18

Abstract

Background: Bronchial challenge tests are used to evaluate bronchial responsiveness in diagnosis and follow-up of asthmatic patients. Challenge induced cough has increasingly been recognized as a valuable diagnostic tool. Various stimuli and protocols have been employed. The aim of this study was to compare cough and dyspnea intensity induced by different stimuli.

Methods: Twenty asthmatic patients underwent challenge tests with methacholine, bradykinin and exercise. Cough was counted during challenge tests. Dyspnea was assessed by modified Borg scale and visual analogue scale. Statistical comparisons were performed by linear mixed-effects model.

Results: For cough evaluation, bradykinin was the most potent trigger (p < 0.01). In terms of dyspnea measured by Borg scale, there were no differences among stimuli (p > 0.05). By visual analogue scale, bradykinin induced more dyspnea than other stimuli (p < or = 0.04).

Conclusion: Bradykinin seems to be the most suitable stimulus for bronchial challenge tests intended for measuring cough in association with bronchoconstriction.

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支气管收缩时咳嗽和呼吸困难:不同刺激的比较。

背景:支气管激发试验在哮喘患者的诊断和随访中用于评估支气管反应性。挑战性咳嗽越来越被认为是一种有价值的诊断工具。采用了各种刺激和方案。本研究的目的是比较不同刺激引起的咳嗽和呼吸困难的强度。方法:对20例哮喘患者进行甲胆碱、缓激肽和运动激发试验。咳嗽计数在激发试验期间。采用改良Borg评分法和视觉模拟评分法评定呼吸困难。采用线性混合效应模型进行统计学比较。结果:在咳嗽评价中，缓激肽是最有效的诱发因素(p < 0.01)。用Borg量表测量呼吸困难，不同刺激间无差异(p > 0.05)。通过视觉模拟评分，缓激肽诱导的呼吸困难明显多于其他刺激(p < or = 0.04)。结论:缓激肽似乎是支气管激发试验中最合适的刺激物，用于测量与支气管收缩相关的咳嗽。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cough (London, England)

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