Identification of gene biomarkers for respiratory syncytial virus infection in a bronchial epithelial cell line.

IF 3.5 Q1 EDUCATION & EDUCATIONAL RESEARCH

Genomic medicine Pub Date : 2008-12-01 Epub Date: 2009-05-15 DOI:10.1007/s11568-009-9080-y

Yuh-Chin T Huang, Zhuowei Li, Xhevahire Hyseni, Michael Schmitt, Robert B Devlin, Edward D Karoly, Joleen M Soukup

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引用次数: 37

Abstract

Respiratory syncytial virus (RSV) infection involves complex virus-host interplay. In this study, we analyzed gene expression in RSV-infected BEAS-2B cells to discover novel signaling pathways and biomarkers. We hybridized RNAs from RSV- or vehicle-treated BEAS-2B to Affymetrix HU133 plus 2.0 microarrays (n = 4). At 4 and 24 h post-infection, 277 and 900 genes (RSV/control ratio >/=2.0 or

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支气管上皮细胞系呼吸道合胞病毒感染基因生物标志物的鉴定。

呼吸道合胞病毒(RSV)感染涉及复杂的病毒-宿主相互作用。在这项研究中，我们分析了rsv感染的BEAS-2B细胞的基因表达，以发现新的信号通路和生物标志物。我们将RSV或载体处理的BEAS-2B的rna与Affymetrix HU133 + 2.0微阵列进行杂交(n = 4)。在感染后4和24 h, 277和900个基因(RSV/对照比>/=2.0或

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Genomic medicine

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