The search for non-linear exposure-response relationships at ambient levels in environmental epidemiology.

Morton Lippmann
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引用次数: 7

Abstract

Environmental exposures to ambient air particulate matter (PM), ozone (O(3)), environmental tobacco smoke (ETS), and to dioxin and related compounds are of considerable public health concern, and risk assessments for them have generally been based on linear, non-threshold models derived from epidemiological study data. While the epidemiological databases for PM, O(3), and ETS have been sufficient to show that adverse health effects are occurring, the relative risks have been quite low, and it has not been possible, to date, to identify thresholds or non-linear relationships for them. For dioxin and related compounds, the evidence for excess cancer risks has been inadequate to establish causality, and there is suggestive evidence that hormesis may have occurred.

环境流行病学中对环境水平非线性暴露-反应关系的研究。
对环境空气颗粒物(PM)、臭氧(O(3))、环境烟草烟雾(ETS)以及二恶英及相关化合物的环境暴露是相当令人关注的公共卫生问题,对它们的风险评估通常基于从流行病学研究数据得出的线性非阈值模型。虽然PM、O(3)和ETS的流行病学数据库已经足以表明正在发生不利的健康影响,但相对风险相当低,而且迄今为止还不可能确定它们的阈值或非线性关系。对于二恶英和相关化合物,过度致癌风险的证据不足以建立因果关系,并且有暗示性证据表明可能已经发生了激效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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