Cognitive impairment in encephalitis: P3 and MRI correlation.

Electromyography and clinical neurophysiology Pub Date : 2009-01-01

J Kalita, U K Misra, A Srivastava

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Abstract

Objective: In view of paucity of studies on P3 in encephalitis, we report clinical, MRI and P3 changes in encephalitis patients.

Design: The diagnosis of encephalitis was based on clinical, MRI, ELISA and/or PCR and categorized into Japanese encephalitis (JE), dengue, herpes (HSE) and nonspecific group. Cognitive functions were evaluated 1 month after the illness when patient was able to cooperate for Mini Mental State examination (MMSE). P3 was carried out by odd ball auditory paradigm recording from Cz, Fz and Pz referred to linked mastoids.

Results: 30 encephalitis patients including 16 JE, 2 HSE and 12 nonspecific whose median age was 24 (13-53) years were prospectively evaluated. P3 was studied after a median duration of 3 months. MMSE was abnormal in 19 patients. CzP3 was abnormal in 6; 5 of whom had abnormal MMSE. MRI was abnormal in 18 showing thalamic lesion in 13, basal ganglia in 3 and cortical in 7 patients. MMSE was abnormal in all the patients with HSE, 81% with JE and 33% with nonspecific encephalitis. P3 was more frequently abnormal in patients with abnormal MMSE and MRI.

Conclusion: Cognitive impairment is common in HSE and JE; abnormal MMSE and MRI are associated with P3 abnormality.

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脑炎认知功能障碍:P3与MRI的相关性。

目的:针对脑炎中P3的研究较少，报道脑炎患者的临床、MRI及P3的变化。设计:脑炎的诊断基于临床、MRI、ELISA和/或PCR，分为日本脑炎(JE)、登革热、疱疹(HSE)和非特异性组。发病1个月后，当患者能够配合简易精神状态检查(MMSE)时，评估患者的认知功能。P3由Cz、Fz和Pz(连接乳突)的奇球听觉范式记录。结果:前瞻性评价脑炎患者30例，其中乙脑16例，HSE 2例，非特异性12例，中位年龄24(13-53)岁。P3在中位持续时间3个月后进行研究。19例患者MMSE异常。6例CzP3异常;其中5例MMSE异常。MRI异常18例，丘脑病变13例，基底节区病变3例，皮层病变7例。所有HSE患者MMSE异常，乙脑81%，非特异性脑炎33%。在MMSE和MRI异常的患者中P3异常较多。结论:认知障碍在HSE和乙脑患者中普遍存在;MMSE和MRI异常与P3异常相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Electromyography and clinical neurophysiology

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