[Antiphospholipid antibodies syndrome in dermatology in Dakar: 11 case report].

Dakar medical Pub Date : 2007-01-01
M Diallo, S O Niang, A Kane, M T Dieng, B Ndiaye
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Abstract

Introduction: Our aim was to report the cutaneous features of antiphospholipid antibodies syndrome in Dermatology in Dakar.

Methods: Our study was retrospective from January 2000 to December 2001. All patients were diagnosed according to the criteria of the international consensus statement in 1999 on the antiphospholipid antibodies.

Results: Eleven cases (all female) were collected with a median age of 28 years. A systemic lupus was associated in 7 cases, a scleroderma in 1 case and mix connectivity in 1 case. The dermatological manifestations found in all patients were necrosis of the extremities (4 cases), purpuric lesions (4), cutaneous ulcers (3), acrocyanosis (2), livedo (1) and subungual splinter hemorrhage (1). The obstetrical incidents were noted in 82% of cases; there were precocious and repeated abortions (in 5 cases), foetal loss (in 4 patients), precocious delivery (in 2 cases), lateness of growth in uterus (in 1 case). It was an arterial thrombosis in 2 cases. The mean level of anticardiolipin antibodies was 60 UGPL and a dissociation of the syphilitic serology was present in 9 patients. A severe thrombopenia in 1 case was observed. The evolution was favorable in 7 patients. In other cases, we noted foetal loss in 2 cases and distal necrosis relapse in 2 cases.

Conclusion: Cutaneous manifestations are diverse. They can be lupus involvements or microcirculatory thrombosis and they make the diagnostic easy.

[达喀尔皮肤病抗磷脂抗体综合征:11例报告]。
简介:我们的目的是报告达喀尔皮肤科抗磷脂抗体综合征的皮肤特征。方法:回顾性研究时间为2000年1月至2001年12月。所有患者均按照1999年抗磷脂抗体国际共识声明的标准进行诊断。结果:11例患者均为女性,中位年龄28岁。系统性狼疮7例,硬皮病1例,混合性连通性1例。所有患者的皮肤病学表现为四肢坏死(4例)、紫癜性病变(4例)、皮肤溃疡(3例)、肢绀(2例)、活斑(1例)、趾下裂出血(1例)。产科事故发生率为82%;早孕反复流产(5例),胎儿丢失(4例),早产(2例),子宫发育迟缓(1例)。2例为动脉血栓形成。抗心磷脂抗体平均水平为60 UGPL, 9例患者出现梅毒血清学分离。1例出现严重血小板减少。7例患者进展有利。在其他病例中,我们注意到2例胎儿丢失和2例远端坏死复发。结论:皮肤表现多样。它们可能是狼疮或微循环血栓形成,它们使诊断变得容易。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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