Diagnosis of infections in newborns using a new particle-mediated immunoassay for serum C-reactive protein.

S Kitahashi, N Tatsumi, S Tagawa, T Matsui, M Higashihata, H Shintaku, S Tomoda, I Tsuda
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引用次数: 2

Abstract

C-reactive protein (CRP) levels were measured using a new particle-mediated immunoassay. Tests for precision and linearity of this method gave satisfactory results. The minimum sensitivity of the assay was 1 ng/ml. Interference by bilirubin (<220mg/l) and haemoglobin (<20g/l) was not observed. Using this method, CRP was assayed as a means of monitoring for infection in newborns up to 72 h after delivery. The pattern of time course elevation curves was similar for both groups (10 healthy subjects and 26 patients), but the serum CRP (ng/ml) of infected newborns rose significantly higher than in healthy subjects at 24 h after birth. The rate of increase of CRP (CRP; ng/ml/h) may be a more useful parameter to detect infection, since a significant change in CRP was apparent only 12 h after birth. The reported method was reliable and the parameters obtained were considered clinically useful for early detection of infection.

用一种新的颗粒介导的血清c反应蛋白免疫分析法诊断新生儿感染
c反应蛋白(CRP)水平采用一种新的颗粒介导免疫分析法测定。方法的精密度和线性度试验结果令人满意。该方法的最低灵敏度为1 ng/ml。胆红素的干扰(
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