Expression of metalloproteinases MMP-2 and MMP-9 in antrochoanal polyps.

American journal of rhinology Pub Date : 2008-07-01 DOI:10.2500/ajr.2008.22.3183

Ozgul Topal, Selim S Erbek, Halil Kiyici, Ozcan Cakmak

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引用次数: 21

Abstract

Background: Matrix metalloproteinase (MMP) 2 and MMP-9 are known to cleave specifically type 4 collagen, which is a major structural component of basement membrane. This is an early step of inflammation. Because of this property they have been studied in chronic sinonasal disorders. The aim of this study was to determine the MMP-2 and MMP-9 expressions in an antrochoanal polyp (ACP).

Methods: We examined tissue samples from 10 ACPs, 10 diffuse nasal polyps, and 10 control nasal mucosa (CM) by immunohistochemistry for MMP-2 and MMP-9 expression.

Results: Most of epithelial and endothelial cells showed positive immunostaining for MMP-2 and MMP-9 in all tissue samples. MMP-2 staining of inflammatory cells showed no difference among the groups (p > 0.05). On the other hand, MMP-9+ inflammatory cells were found to be significantly increased in ACP and diffuse nasal polyps when compared with CM (p < 0.05).

Conclusion: MMP-9-expressing inflammatory cells could play a role in the pathophysiology of ACP as well as nasal polyps.

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金属蛋白酶MMP-2和MMP-9在鼻后鼻息肉中的表达。

背景:基质金属蛋白酶(Matrix metalloproteinase, MMP) 2和MMP-9被认为能够特异地切割4型胶原，而4型胶原是基底膜的主要结构成分。这是炎症的早期阶段。由于这一特性，它们已被研究用于慢性鼻窦疾病。本研究的目的是测定MMP-2和MMP-9在肛管息肉(ACP)中的表达。方法:采用免疫组化方法检测10例acp、10例弥漫性鼻息肉和10例对照鼻黏膜(CM)组织样本中MMP-2和MMP-9的表达。结果:在所有组织样本中，大多数上皮细胞和内皮细胞的MMP-2和MMP-9免疫染色均呈阳性。各组炎症细胞MMP-2染色差异无统计学意义(p > 0.05)。另一方面，与CM组相比，ACP组和弥漫性鼻息肉组中MMP-9+炎性细胞明显增加(p < 0.05)。结论:表达mmp -9的炎性细胞可能参与ACP及鼻息肉的病理生理过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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American journal of rhinology

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