[Osteonecrosis of the jaws: a secondary effect of bisphosphonates].

Revue belge de medecine dentaire Pub Date : 2007-01-01
J Schortinghuis, L Meijndert, J G A M De Visscher, M J H Witjes
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Abstract

When treated with intravenous bisphosphonates to prevent bone resorption, 4-10% of the patients may develop osteonecrosis of the jaws a side effect. The osteonecrosis is usually preceded by an invasive dental procedure such as the removal of a tooth. Treatment of the osteonecrosis should be conservative using aseptic mouth rinses, oral antibiotics and small debridement. It seems advisable to have a dental check-up before starting using intravenous bisphosphonates, since a potential dental infections can be treated before the bone healing capacity is reduced by the bisphosphonates.

[颌骨骨坏死:双磷酸盐的继发效应]。
当静脉注射双膦酸盐以防止骨吸收时,4-10%的患者可能出现颌骨骨坏死的副作用。骨坏死之前通常会进行侵入性牙科手术,如拔牙。骨坏死的治疗应保守,使用无菌漱口水、口服抗生素和小范围清创。在开始静脉注射双膦酸盐之前,最好先做一次牙齿检查,因为潜在的牙齿感染可以在双膦酸盐降低骨愈合能力之前得到治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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