{"title":"Age-related change in the axonal diameter of the olfactory nerve in mouse lamina propria.","authors":"Kenta Watanabe, Kenji Kondo, Tatsuya Yamasoba, Kimitaka Kaga","doi":"10.1080/03655230701597598","DOIUrl":null,"url":null,"abstract":"<p><strong>Conclusion: </strong>The present study demonstrated the age-related decrease in the axonal diameter of the olfactory nerve. This finding may represent the maturational change of the olfactory receptor neurons.</p><p><strong>Objectives: </strong>The aim of this study was to investigate age-related changes in the axonal diameter of the olfactory nerve in the lamina propria.</p><p><strong>Materials and methods: </strong>Female ICR mice, postnatal age 10 days, 3 months, 7 months, and 16 months, were studied. The electron micrographs of septal olfactory mucosa were used to measure the axonal diameters of olfactory nerves.</p><p><strong>Results: </strong>The distribution of the diameter shifted toward the thinner side between 10-day-old and 3-month-old mice. The axonal diameter showed significant decreases (p < 0.001) from the age of 10 days to that of 3 months.</p>","PeriodicalId":7027,"journal":{"name":"Acta oto-laryngologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/03655230701597598","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta oto-laryngologica. Supplementum","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/03655230701597598","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Conclusion: The present study demonstrated the age-related decrease in the axonal diameter of the olfactory nerve. This finding may represent the maturational change of the olfactory receptor neurons.
Objectives: The aim of this study was to investigate age-related changes in the axonal diameter of the olfactory nerve in the lamina propria.
Materials and methods: Female ICR mice, postnatal age 10 days, 3 months, 7 months, and 16 months, were studied. The electron micrographs of septal olfactory mucosa were used to measure the axonal diameters of olfactory nerves.
Results: The distribution of the diameter shifted toward the thinner side between 10-day-old and 3-month-old mice. The axonal diameter showed significant decreases (p < 0.001) from the age of 10 days to that of 3 months.
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