Switching NSAIDs in practice: insights from the Previcox (firocoxib) Experience Trial.

Veterinary Therapeutics Pub Date : 2007-01-01
William G Ryan, Katherine Moldave, Doug Carithers
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Abstract

Veterinarians currently have a choice of six registered NSAIDs for use in the management of canine osteoarthritis. There is a need for data to clarify whether there is an increased risk of side effects occurring in the event of a switch between different members of the NSAID class. In this retrospective analysis of extensive data collected in the 1,000 dog Previcox (firocoxib, Merial) Experience Trial, the incidence of side effects in dogs reported as treated with an NSAID 7 days or less before enrollment was compared with that in dogs reported as not having received an NSAID in the equivalent period. Statistical analysis of the data indicates that observation of an interval of up to 1 week between beginning treatment with firocoxib and cessation of treatment with a different NSAID was not associated with any increased risk of adverse events.

在实践中切换非甾体抗炎药:来自Previcox (firocoxib)经验试验的见解。
兽医目前有六种注册的非甾体抗炎药用于治疗犬骨关节炎。需要数据来阐明在非甾体抗炎药类别的不同成员之间切换是否会增加副作用的风险。在这项对1000只狗进行的Previcox (firocoxib, Merial)经验试验中收集的大量数据的回顾性分析中,将在入组前7天或更短时间内接受非甾体抗炎药治疗的狗的副作用发生率与同期未接受非甾体抗炎药治疗的狗的副作用发生率进行了比较。数据的统计分析表明,观察到在开始使用firocoxib和停止使用不同的非甾体抗炎药治疗之间长达1周的间隔与不良事件的风险增加无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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