[Why screening for a renal artery stenosis?].

D Stéphan, C Griffon, A Hamade, C Jahn, M Welsch, C Mounier-Vehier
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Abstract

Diagnosis of renal artery stenosis (RAS) should be discussed in numerous clinical situations including refractory high blood pressure (HBP), HBP in a polyvascular patient, degradation of renal function following renin angiotensin inhibitor or flash pulmonary edema. Ultrasound-doppler coupled with gadolinium-enhanced MR or CT angiography has proven adequate for most patients with RAS. Digital subtraction angiography should be limited to revascularisation procedures. Functional testing are not sensitive or specific enough because the degree of renin activation differs widely among patients with RAS. Renal percutaneous angioplasty induces a light to moderate decrease in blood pressure, has no effect on renal function but allows to reduce the number of anti-hypertensive drugs. Stenting completed angioplasty is worthwhile in most patients with atherosclerotic RAS. ACE inhibitors decrease mortality and increase renal function in patients with RAS.

【为什么要筛查肾动脉狭窄?】
肾动脉狭窄(RAS)的诊断应在多种临床情况下进行讨论,包括难治性高血压(HBP)、多血管患者的HBP、肾素血管紧张素抑制剂后肾功能退化或闪发性肺水肿。超声多普勒结合钆增强磁共振或CT血管造影已被证明对大多数RAS患者是足够的。数字减影血管造影应限于血运重建手术。功能检测不够敏感或特异性,因为RAS患者肾素激活程度差异很大。肾经皮血管成形术可使血压轻度至中度下降,对肾功能无影响,但可减少降压药的用量。对于大多数动脉粥样硬化性RAS患者,支架置入术是值得的。ACE抑制剂可降低RAS患者的死亡率并增加肾功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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