V A Trufakin, A V Shurlygina, S V Michurina, L V Verbitskaja, G I Litvinenko, I G Kovshik, N G Panteleeva, E V Melnikova, M V Bitchaeva
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引用次数: 0
Abstract
The aim of this study is to investigate the influence of experimental desynchronosis on the immune system and estimate benzo[a]pyrene (BP) influence on the immune reactivity of mice under the condition of desyncronosis (DS) in comparison with intact organisms. Mice (CBA X C57BL)F1 were kept under constant light during two weeks and natural alternation of darkness and light (control group). Animals of the two groups received benzo[a]pyrene solution in olive oil. The existence of diurnal variation of cell populations of lymphoid organs and blood, humoral immune response to SRBC were revealed. Changes of diurnal dynamics of these parameters and decrease of humoral immune response to SRBC have been observed in animals kept under constant light in comparison with animals kept under standard light conditions. It is likely to indicate the development of internal DS. BP influenced the cellular composition and immune response of intact and DS animals in a different way. So, the changes of light regime lead to development of the internal DS of immune system that influenced its functional capacity and sensitivity to damaging effect of chemical ecological factor.
本研究的目的是探讨实验性去同步症对免疫系统的影响，并与完整生物体比较，估计苯并[a]芘(BP)对去同步症(DS)小鼠免疫反应性的影响。小鼠(CBA X C57BL)F1持续光照2周，自然明暗交替(对照组)。两组动物均接受橄榄油中苯并[a]芘溶液。淋巴器官和血液细胞群的昼夜变化，揭示了对SRBC的体液免疫反应。与标准光照条件下的动物相比，在恒定光照条件下观察到这些参数的昼夜动态变化和对SRBC的体液免疫反应的降低。这可能预示着内部DS的发展。BP以不同的方式影响完整动物和DS动物的细胞组成和免疫应答。因此，光照条件的变化导致了免疫系统内部DS的发育，影响了免疫系统的功能和对化学生态因子破坏作用的敏感性。
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