Acute hepatitis A infection in children: a 20-year experience of a medical center in Southern Taiwan.

Yu-Chieh Chen, Li-Tung Huang, Sheng-Ming Wang, Mao-Meng Tiao, Jien-Wei Liu
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Abstract

Background: Taiwan is currently nonendemic for hepatitis A infection, but sporadic cases are reported occasionally. The presenting symptoms of acute hepatitis A (AHA) infection in children are often nonspecific and may be easily misdiagnosed as general gastrointestinal illness.

Methods: We conducted this study to identify the relevant presenting symptoms and laboratory findings of AHA in children. The medical records of all patients younger than 18 years old admitted to Kaohsiung Chang Gang Memorial Hospital from July 1986 to June 2004 under the diagnosis of AHA were reviewed. There were 29 pediatric patients admitted with the diagnosis of AHA, including 16 male patients and 13 female patients.

Results: Poor appetite, malaise, abdominal pain, vomiting and fever were the leading constitutional symptoms. Jaundice and tea-colored urine were the most relevant hepatobiliary presentations. Elevation of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, direct and indirect bilirubin was common, although other hematology and biochemistry examinations were within normal limits on most occasions. There was no mortality in our series. A slightly increasing prevalence of AHA was noted over the two decades of the study period, although it was not statistically significant.

Conclusions: Our results found that children with AHA tended to present with non-specific gastrointestinal symptoms and acute liver function deterioration. Elevation of hepatic aminotransferase and alkaline phosphatase with cholestasis was common.

儿童急性甲型肝炎感染:台湾南部某医疗中心20年经验。
背景:台湾目前甲型肝炎感染非地方性,但偶尔有散发病例报告。儿童急性甲型肝炎(AHA)感染的症状通常是非特异性的,很容易误诊为一般胃肠道疾病。方法:我们进行了这项研究,以确定儿童AHA的相关表现症状和实验室结果。本文回顾1986年7月至2004年6月在高雄长港纪念医院诊断为AHA的所有18岁以下患者的病历。确诊为AHA的患儿29例,其中男16例,女13例。结果:食欲不振、不适、腹痛、呕吐、发热为主要体质症状。黄疸和茶色尿是最相关的肝胆表现。天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶、直接和间接胆红素升高常见,但其他血液学和生化检查多数在正常范围内。在我们的研究中没有死亡率。在20年的研究期间,AHA的患病率略有增加,尽管没有统计学意义。结论:我们的研究结果发现,患有AHA的儿童往往表现为非特异性胃肠道症状和急性肝功能恶化。肝转氨酶和碱性磷酸酶升高常伴胆汁淤积。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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